Highly enantioselective hydrogenation of enol acetates catalyzed by Ru-TunaPhos complexes.
نویسندگان
چکیده
[reaction: see text] The chiral disphosphines with tunable dihedral angles (TunaPhos) have been used for asymmetric hydrogenation of enol acetates and dihedral-angle-dependent enantioselectivities were observed. C2-TunaPhos has been proved to be effective for Ru-catalyzed asymmetric hydrogenation of electron-deficient and other enol acetates.
منابع مشابه
Enantioselective RH-catalyzed hydrogenation of enol acetates and enol carbamates with monodentate phosphoramidites.
[reaction: see text] Monodentate phosphoramidites, in particular PipPhos and its octahydro analogue, are excellent ligands for the rhodium-catalyzed asymmetric hydrogenation of aromatic enol acetates, enol carbamates, and 2-dienol carbamates up to 98% ee. These latter substrates were hydrogenated selectively to the carbamates of the allyl alcohol.
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ورودعنوان ژورنال:
- Organic letters
دوره 4 25 شماره
صفحات -
تاریخ انتشار 2002